Nicorandil and Atorvastatin Attenuate Carbon Tetrachloride - Induced Liver Fibrosis in Rats.

Nicorandil and Atorvastatin Attenuate Carbon Tetrachloride - Induced Liver Fibrosis in Rats. Immunopharmacol Immunotoxicol. 2020 Sep 28;:1-29 Authors: Abdel-Sattar AR, Abo-Saif AA, Aboyoussef AM Abstract The present study aimed to evaluate the possible hepatoprotective effects of nicorandil and atorvastatin against experimentally induced liver fibrosis.Wistar male rats wereassigned tofivegroups;control group, fibrosis group, the remaining three groups received in addition to CCl4, N-acetyl cysteine (300 mg/kg), nicorandil(15 mg/kg) and atorvastatin (20 mg/kg), respectively.Liver fibrosis was induced by intraperitoneal injection of rats with CCl4(2ml/kg), twice weekly for five consecutive weeks.All treatments were administereddaily starting from the first day of fibrosis inductionfor five consecutive weeks.By the end of the experiment,fibrosis biomarkers [hepatic transforming growth factor β1 (TGF-β1) and hydroxyproline (HYP)], liver function [serum alanine transaminase (ALT), aspartate transaminase (AST), albumin and total bilirubin]were assessed. Moreover, lipid profile [total cholesterol, serum triglycerides, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)],inflammatorybiomarkers [hepatic myeloperoxidase (MPO), serum tumor necrosis factor alpha (TNF-α)], relative liver weight] and oxidative stress biomarkers [malondialdehyde (MDA), glutathione (GSH) and catalase (CAT)] were eval...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research