Mouse bone marrow-derived mesenchymal stem cells acquire immunogenicity concurrent with differentiation to insulin-producing cells.

CONCLUSIONS: MSCs acquire immunogenicity after differentiation to functional IPCs, which might cause decreased efficacy in the case of allogeneic transplantation. Careful precautions might be critical for saving the IPCs against the detrimental allogeneic responses. PMID: 32962814 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32962814?dopt=Abstract

Source: Immunobiology - August 31, 2020 Category: Allergy & Immunology Authors: Mohammadi N, Mardomi A, Hassannia H, Enderami SE, Ranjbaran H, Rafiei A, Abediankenari S Tags: Immunobiology Source Type: research