Dynamics of bla KPC-2 dissemination from non-CG258 Klebsiella pneumoniae to other Enterobacterales via IncN plasmids in an area of high endemicity.

Dynamics of bla KPC-2 dissemination from non-CG258 Klebsiella pneumoniae to other Enterobacterales via IncN plasmids in an area of high endemicity. Antimicrob Agents Chemother. 2020 Sep 21;: Authors: Rada AM, De La Cadena E, Agudelo C, Capataz C, Orozco N, Pallares C, Dinh AQ, Panesso D, Ríos R, Diaz L, Correa A, Hanson BM, Villegas MV, Arias CA, Restrepo E Abstract Carbapenem-resistant Enterobacterales (CRE) pose a significant threat to global public health. The most important mechanism for carbapenem resistance is the production of carbapenemases. Klebsiella pneumoniae carbapenemase (KPC) represents one of the main carbapenemases worldwide. Complex mechanisms of bla KPC dissemination have been reported in Colombia, a country with high endemicity of carbapenem resistance. Here, we characterized the dynamics of dissemination of bla KPC gene among CRE infecting and colonizing patients in three hospitals localized in a highly endemic area of Colombia (2013 and 2015). We identified the genomic characteristics of KPC-producing Enterobacterales recovered from patients infected/colonized and reconstructed the dynamics of dissemination of bla KPC-2 using both short and long read sequencing. We found that spread of bla KPC-2 among Enterobacterales in the participating hospitals was due to intra and inter-species horizontal gene transfer (HGT) mediated by promiscuous plasmids associated to transposable elements that was originated from a multi-species outb...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research

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Conclusions TheK. pneumoniae ST11 NDM-1 outbreak has dramatically expanded in Poland since 2012, which may bring about a countrywide endemic situation in the near future. In addition, the so-far limitedK. pneumoniae ST147 NDM-1 outbreak plus multiple NDM imports from different countries were observed in 2015 –16.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research
Conclusion This study revealed that Enterococcus species with biofilm potentials and extracellular virulence properties extensively occur in retail RTE shrimps. A significant number of isolated strains are resistant to antibiotics and harbor resistant and virulent genes, denoting a significant route of resistance and virulence dissemination to bacteria in humans. There is an inadequate understanding of the intricacies of antibiotic-resistant enterococci of food origin that belong to enterococci aside from E. faecium and E. faecalis. Findings from this study reveal detailed antibiotic resistance of E. durans, E. casselifla...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 006 Our medical student who caught shigella on a Nepalese elective has a thirst for adventure. They plan to help at a Bangladesh refugee camp but the latest CDC report states there have been some cases of cholera. They’ve done a little bit of reading and want your help to teach them all about cholera and how they may prepare and best serve their new community. Questions: Q1. What is cholera and how is it transmitted? Answer and inte...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine cholera diarrhoea john snow ORS rice water diarrhoea watery diarrhoea Source Type: blogs
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 004 A medical student who has just returned from their elective in Nepal presents with 1 week of bloody diarrhoea. He has been in the lowlands and stayed with a family in the local village he was helping at. It started three days before he left and he decided to get home on the plane in the hope it would settle. He is now opening his bowels 10x a day with associated cramps, fevers and has started feeling dizzy. Questions: Q1. What is dyse...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine amoebic dysentery bacillary dysentery e.histolytica entamoeba histolytica shigellosis Source Type: blogs
Discussion Cholera is caused by more than 200 serogroups of Vibrio cholerae, a Gram-negative rod that is waterborne. Only two (serogroup O1 which causes about 99% of the cases, and O139) cause disease. There are biotypes of each of these serotypes. The only known hosts are humans. The organism colonizes the epithelial lining of the gut. Cholera toxin is produced by some species and if produced binds to specific receptors on host cells, activating a series of steps which cases massive loss of sodium, potassium, chloride, hydrogen carbonate, and fluids in vomitus and feces. A review of causes of diarrhea can be found here. ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Adenoviruses are endemic, primarily causing respiratory and ocular (pharyngoconjunctival fever) symptoms and gastroenteritis infections in infants and children. They also cause epidemic keratoconjunctivitis, pneumonia in military recruits and severe, life-threatening infections in transplant recipients. The hardy non-enveloped virus resists environmental degradation and is transmitted by aerosolized droplets, fomites and faecal-oral spread. Outbreaks occur in medical, day care, military and other facilities where people live in close proximity.
Source: Medicine - Category: Internal Medicine Authors: Tags: Viral infections Source Type: research
Publication date: Available online 6 September 2017 Source:Research in Microbiology Author(s): Kaboré Saidou, Philippe Cecchi, Thomas Mosser, Toubiana Mylène, Traoré Oumar, Aboubakar S. Ouattara, Alfred S. Traoré, Nicolas Barro, Rita R. Colwell, Patrick Monfort Africa is currently an important region in which cholera epidemics occur. Little is known about the presence of Vibriocholerae in freshwater bodies in Africa. There are ca. 1,700 lakes and reservoirs in Burkina Faso, most of which have been built within recent decades to secure water resources. The purpose of this study was to investigat...
Source: Research in Microbiology - Category: Microbiology Source Type: research
ll AJ Abstract Norovirus is the leading cause of endemic and epidemic acute gastroenteritis in the United States (1). New variant strains of norovirus GII.4 emerge every 2-4 years (2-4) and are often associated with increased disease and health care visits (5-7). Since 2009, CDC has obtained epidemiologic data on norovirus outbreaks from state health departments through the National Outbreak Reporting System (NORS) (8) and laboratory data through CaliciNet (9). NORS is a web-based platform for reporting waterborne, foodborne, and enteric disease outbreaks of all etiologies, including norovirus, to CDC. CaliciNet, ...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
CONCLUSION: Enhanced surveillance of diarrhoeal diseases (enteric pathogens) within cholera endemic regions, will serve as an early warning signal, and reduce fatalities associated with infective diarrhoea. PMID: 26339088 [PubMed - in process]
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
Summary Many wild swine populations in different parts of the World have experienced an unprecedented demographic explosion that may result in increased exposure of humans to wild swine zoonotic pathogens. Interactions between humans and wild swine leading to pathogen transmission could come from different ways, being hunters and game professionals the most exposed to acquiring infections from wild swine. However, increasing human settlements in semi‐natural areas, outdoor activities, socio‐economic changes and food habits may increase the rate of exposure to wild swine zoonotic pathogens and to potentially emerging pa...
Source: Transboundary and Emerging Diseases - Category: Veterinary Research Authors: Tags: Review Article Source Type: research
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