γ-Aminobutyric Acid Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inducing TNFAIP3.

CONCLUSION: Our results suggested that GABA treatment positively regulated osteogenic differentiation by upregulating TNFAIP3, while no obvious effect on osteoclastic differentiation was detected. Therefore, our results provide a potential gene therapy for the treatment of osteoporosis and low bone mineral density. PMID: 32951573 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32951573?dopt=Abstract

Source: Current Gene Therapy - September 23, 2020 Category: Genetics & Stem Cells Authors: Li H, Wu Y, Huang N, Zhao Q, Yuan Q, Shao B Tags: Curr Gene Ther Source Type: research