The capacity of the ovarian cancer tumor microenvironment to integrate inflammation signaling conveys a shorter disease-free interval.

CONCLUSIONS: Multi-omic profiling of ovarian tumor samples pre- and post-NACT provides unique insight into chemo-induced changes to the tumor microenvironment. We identified a novel IL-6/IER3 signaling axis that may drive chemo-resistance and disease recurrence.
PMID: 32928797 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 13, 2020 Category: Cancer & Oncology Authors: Jordan K, Sikora MJ, Slansky JE, Minic A, Richer JK, Moroney MR, Hu J, Wolsky RJ, Watson ZL, Yamamoto TM, Costello JC, Clauset A, Behbakht K, Kumar TR, Bitler BG Tags: Clin Cancer Res Source Type: research