Molecules, Vol. 25, Pages 4250: In Vitro Antimicrobial Activity of Isopimarane-Type Diterpenoids
Molecules, Vol. 25, Pages 4250: In Vitro Antimicrobial Activity of Isopimarane-Type Diterpenoids
Molecules doi: 10.3390/molecules25184250
Authors:
Vera M. S. Isca
Joana Andrade
Ana Sofia Fernandes
Paulo Paixão
Clara Uriel
Ana María Gómez
Noélia Duarte
Patrícia Rijo
The antimicrobial evaluation of twelve natural and hemisynthetic isopimarane diterpenes are reported. The compounds were evaluated against a panel of Gram-positive bacteria, including two methicillin-resistant Staphylococcus aureus (MRSA) strains and one vancomycin-resistant Enterococcus (VRE) strain. Only natural compounds 7,15-isopimaradien-19-ol (1) and 19-acetoxy-7,15-isopimaradien-3β-ol (6) showed promising results. Isopimarane (1) was the most active, showing MIC values between 6.76 µM against S. aureus (ATCC 43866) and 216.62 µM against E. faecalis (FFHB 427483) and E. flavescens (ATCC 49996). Compound (6) showed moderated activity against all tested microorganisms (MIC between value 22.54 and 45.07 µM). These compounds were found to be active against the methicillin-sensitive strains of S. aureus (CIP 106760 and FFHB 29593), showing MIC values of 13.55 (1) and 22.54 (6) µM. Both compounds were also active against vancomycin-resistant E. faecalis (ATCC 51299) (MIC values of 54.14 and 45.07 µM, respectively). In addition, the cytotoxicity of nine compounds 7,15-isopimaradien-3β,19-diol (2...
Source: Molecules - Category: Chemistry Authors: Vera M. S. Isca Joana Andrade Ana Sofia Fernandes Paulo Paix ão Clara Uriel Ana Mar ía Gómez No élia Duarte Patr ícia Rijo Tags: Communication Source Type: research
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