Kupffer cells: Inflammation pathways and cell-cell interactions in alcohol-associated liver disease.

Kupffer cells: Inflammation pathways and cell-cell interactions in alcohol-associated liver disease. Am J Pathol. 2020 Sep 10;: Authors: Slevin E, Baiocchi L, Wu N, Ekser B, Sato K, Lin E, Ceci L, Chen L, Lorenzo SR, Xu W, Kyritsi K, Meadows V, Zhou T, Kundu D, Han Y, Kennedy L, Glaser S, Francis H, Alpini G, Meng F Abstract Chronic alcohol consumption is linked to the development of alcohol-associated liver disease (ALD). This disease is characterized by a clinical spectrum ranging from steatosis to hepatocellular carcinoma (HCC). Several cell types are involved in ALD progression including hepatic macrophages. Kupffer cells (KCs) are the resident macrophages of the liver involved in the progression of ALD by activating pathways that lead to the production of cytokines and chemokines. Additionally, KCs are involved in the production of reactive oxygen species (ROS). ROS are linked to the induction of oxidative stress and inflammation in the liver. These events are activated by the bacterial endotoxin, lipopolysaccharide (LPS) that is released from the gastrointestinal (GI) tract through the portal vein to the liver. LPS is recognized by receptors on KCs which are responsible for triggering several pathways that activate pro-inflammatory cytokines involved in alcohol-induced liver injury. Additionally, KCs activate hepatic stellate cells (HSC) that are involved in liver fibrosis. Novel strategies to treat ALD aim at targeting Kupffer...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research