Blood-based and Imaging-Based Biomarker Outcomes for Patients with Pancreatic Ductal Adenocarcinoma Treated with Different Radiotherapy Techniques

Different prognostic markers have been identified in pancreatic cancer, including blood-based and imaging-based biomarkers. For example, lymphopenia can occur in patients receiving radiation therapy (RT) and is associated with decreased survival in several malignancies, including pancreatic ductal adenocarcinoma (PDAC) (Venkatesulu B, et al. Crit Rev Oncol Hematol 2018). Notably, prior work showed that 5 fractions of pancreas stereotactic radiation therapy (SBRT) resulted in less lymphopenia and an improved overall survival (OS) than chemoradiation (CRT) given over 5-6 weeks (Wild A, et al.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research