Human kidney organoids produce functional renin

Renin production by the kidney is of vital importance for salt, volume, and blood pressure homeostasis. The lack of human models hampers investigation into the regulation of renin and its relevance for kidney physiology. To develop such a model, we used human induced pluripotent stem cell derived kidney organoids to study the role of renin and the renin-angiotensin system in the kidney. Extensive characterization of the kidney organoids revealed kidney-specific cell populations consisting of podocytes, proximal and distal tubular cells, stromal cells and endothelial cells.

Source: Kidney International - September 8, 2020 Category: Urology & Nephrology Authors: Anusha S. Shankar, Zhaoyu Du, Hector Tejeda Mora, Thierry P.P. van den Bosch, Sander S. Korevaar, Ingrid M. Van den Berg – Garrelds, Eric Bindels, Carmen Lopez-Iglesias, Marian Clahsen-van Groningen, Joost Gribnau, Carla C. Baan, A.H. Jan Danser, Ewout Tags: basic research Source Type: research