Reduction in MicroRNA-4488 Expression Induces NF κB Translocation in Venous Endothelial Cells Under Arterial Flow

ConclusionWe showed that ALSS triggered the COX-2/NF κB pathway to induce vEC inflammation with a reduction in miR-4488. Combination of SC-236 and L-Arg prevented ALSS-induced vEC damage, thus, shows high potential for preventing vein graft diseases.

http://link.springer.com/10.1007/s10557-020-06944-8

Source: Cardiovascular Drugs and Therapy - September 8, 2020 Category: Cardiology Source Type: research