Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients.

Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients. J Zhejiang Univ Sci B. 2020 Sept.;21(9):740-744 Authors: Suo SS, Li CY, Zhang Y, Wang JH, Lou YJ, Yu WJ, Jin J Abstract Acute lymphocytic leukemia (ALL) is one of the most common malignancies, especially in young people. Combination chemotherapy for ALL typically includes corticosteroids (Kantarjian et al., 2000). Hyperglycemia is a well-recognized complication of corticosteroids, and chemotherapy-induced diabetes (CID) is not uncommon (27.5%-37.0%) during the treatment of ALL (Hsu et al., 2002; Weiser et al., 2004; Alves et al., 2007). Besides the effect of corticosteroids, potential factors triggering hyperglycemia in ALL also include direct infiltration of the pancreas by leukemia cells and β cell dysfunction induced by chemotherapeutic agents such as L-asparagine (Mohn et al., 2004). PMID: 32893530 [PubMed - in process]
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