Pharmacokinetics and Pharmacodynamics of 3 Doses of Oral-Mucosal Dexmedetomidine Gel for Sedative Premedication in Women Undergoing Modified Radical Mastectomy for Breast Cancer.

CONCLUSIONS: Provided that it is administered 60-120 minutes before surgery, sublingual administration of DEX formulated as an oral-mucosal gel may provide a safe and practical means of sedative premedication in adults. PMID: 32889844 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32889844?dopt=Abstract

Source: Anesthesia and Analgesia - August 31, 2020 Category: Anesthesiology Authors: Mohamed SA, Abdel-Ghaffar HS, Hassan NA, El Sherif FA, Shouman SA, Omran MM, Hassan SB, Allam AAAE, Sayed DG Tags: Anesth Analg Source Type: research