Mid-Pregnancy Polyunsaturated Fatty Acid Levels in Association with Child Autism Spectrum Disorder in a California Population-Based Case-Control Study.

Mid-Pregnancy Polyunsaturated Fatty Acid Levels in Association with Child Autism Spectrum Disorder in a California Population-Based Case-Control Study. Am J Epidemiol. 2020 Sep 02;: Authors: Lyall K, Windham GC, Snyder NW, Kuskovsky R, Xu P, Bostwick A, Robinson L, Newschaffer CJ Abstract Polyunsaturated fatty acids (PUFAs) are critical for brain development and have been linked with neurodevelopmental outcomes. We conducted a population-based case control study in California to examine the association between PUFAs measured in mid-pregnancy serum samples and child autism spectrum disorder (ASD). ASD cases (n = 499) were identified through the Department of Developmental Services and matched to live-birth population controls (n = 502) on birth month, year (2010-2011), and sex. Crude and adjusted logistic regression models were used to examine associations. Secondary analyses examined ASD with and without co-occurring intellectual disability (ID; n = 67 and 432 respectively), and effect modification by sex and ethnicity. No clear patterns emerged, though there was a modest inverse association with the top quartile of linoleic acid (highest versus lowest quartile, adjusted OR = 0.74, 95% CI: 0.49, 1.11; P for trend = 0.10). Lower levels of total and ω 3 PUFAs were associated with ASD with ID (lowest decile versus deciles 4-7, total PUFA adjusted OR = 2.78 95% CI: 1.13, 6.82) but not ASD without ID. We did not observe evide...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research