Hrd1-mediated ACLY Ubiquitination alleviate NAFLD in db/db mice

The functions of Acly in regulating nonalcoholic fatty liver disease (NAFLD) have been identified; however, the dynamic control of Acly expression under the pathological state of metabolic disorders has not been fully elucidated. Previous studies reported an ubiquitin-proteasome –mediated degradation of Acly, but the mechanism is still largely unknown.

Source: Metabolism - Clinical and Experimental - August 31, 2020 Category: Biomedical Science Authors: Kai Li, Kaini Zhang, Hai Wang, Yangyang Wu, Nuoqi Chen, Jinfeng Chen, Chen Qiu, Pengpeng Cai, Min Li, Xiubin Liang, Dongming Su Source Type: research