The indication for fertility preservation in women with Turner syndrome should not only be based on the ovarian reserve but also on the genotype and expected future health status

ABSTRACTFertility preservation in women with Turner syndrome is highly controversial. Some strongly recommend freezing of ovarian tissue at young age, others don ’t. The controversy is partly due to different perspectives and professions. Biologists prefer to freeze young ovaries with high follicle density, reproductive physicians want to avoid risky operations and iatrogenic infertility by removing one ovary and cardiologists and obstetricians warn agains t the risks of later pregnancies. Accordingly, fertility preservation in young women with Turner syndrome is more than freezing of ovarian tissue or oocytes. Fertility preservation requires a balanced decision considering the conservation of fertility, the protection of reproductive health and futur e health consequences. Therefore, fertility preservation strategies should be based not only on the individual ovarian reserve but also on the genotype and the expected cardiac health status to decide what is the best option: to freeze tissue or alternatively to wait and see.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: COMMENTARY Source Type: research