Researchers find potential to make brain cancers in children respond better to treatment

(McMaster University) Research has identified a small molecule compound that can activate the Wnt pathway in non-Wnt subtypes of medulloblastoma, making these aggressive forms of cancer more responsive to therapies. The work also found the Wnt pathway, which has historically been considered cancer-promoting, to function as a cancer inhibitor in certain contexts.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

Related Links:

(Medical University of South Carolina) With this Rally Foundation grant, MUSC Hollings Cancer Center researcher Jezabel R. Blanco, Ph.D., will explore how the developmental pathway Sonic hedgehog gets activated in patients with mutations in the tumor suppressor P53 in medulloblastoma and the drivers of the stem cells of these tumors.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
The sonic hedgehog subtype of medulloblastoma (SHH MB) is associated with treatment failure and poor outcome. Current strategies utilizing whole brain radiation therapy result in deleterious off-target effects on the normal developing childhood brain. Most conventional chemotherapies remain limited by ineffective blood–brain barrier (BBB) penetrance. These challenges signify an unmet...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Brain tumors are the most common solid cancer in children younger than 15 years old.[1] Radiation therapy (RT) remains integral to the treatment of pediatric brain tumors, having significantly improved disease prognosis for common malignant tumors such as medulloblastomas: in average-risk disease, the 5-year survival for these tumors is now at 70-80%.[2,3] Elevated 5-year survival rates have also been achieved through the use of RT as a stand-alone therapy in the treatment of germinomas.[4] Despite having contributed to the overall survival benefit experienced by patients, such therapeutic approaches are associated with lo...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Conclusions: Normal tissue sparing was achieved regardless of patient age for infratentorial tumours. However, for supratentorial tumours, there was a dosimetric advantage of IMPT across 9 vs. 13-year-old patients.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSIONS: Our results suggest that AsiDNA is an attractive candidate to improve radiation therapy in MB, with no indication of additional toxicity in developing brain tissues. PMID: 32900798 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
D. Taylor Rafael Roesler Neurotrophins are a family of secreted proteins that act by binding to tropomyosin receptor kinase (Trk) or p75NTR receptors to regulate nervous system development and plasticity. Increasing evidence indicates that neurotrophins and their receptors in cancer cells play a role in tumor growth and resistance to treatment. In this review, we summarize evidence indicating that neurotrophin signaling influences medulloblastoma (MB), the most common type of malignant brain cancer afflicting children. We discuss the potential of neurotrophin receptors as new therapeutic targets for the treatment of...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
mino Valeria Pensotti Siranoush Manoukian Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder caused by mutations in the TP53 gene, predisposing to a wide spectrum of early-onset cancers, including brain tumors. In medulloblastoma patients, the role of TP53 has been extensively investigated, though the prevalence of de novo mutations has not been addressed. We characterized TP53 mutations in a monocentric cohort of consecutive Sonic Hedgehog (SHH)-activated medulloblastoma patients. Germline testing was offered based on tumor p53 immunostaining positivity. Among 24 patients, three (12.5%) showed tumor p53 ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
mino Valeria Pensotti Siranoush Manoukian Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder caused by mutations in the TP53 gene, predisposing to a wide spectrum of early-onset cancers, including brain tumors. In medulloblastoma patients, the role of TP53 has been extensively investigated, though the prevalence of de novo mutations has not been addressed. We characterized TP53 mutations in a monocentric cohort of consecutive Sonic Hedgehog (SHH)-activated medulloblastoma patients. Germline testing was offered based on tumor p53 immunostaining positivity. Among 24 patients, three (12.5%) showed tumor p53 ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conditions:   Anaplastic Ependymoma;   Atypical Teratoid/Rhabdoid Tumor;   Central Nervous System Germ Cell Tumor;   Choroid Plexus Carcinoma;   Intracranial Myeloid Sarcoma;   Malignant Brain Neoplasm;   Malignant Glioma;   Medulloblastoma;   Primitive Neuroectodermal Tumor;   Recur rent Anaplastic Ependymoma;   Recurrent Atypical Teratoid/Rhabdoid Tumor;   Recurrent Malignant Brain Neoplasm;   Recurrent Malignant Glioma; &nb...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Brain | Brain Cancers | Cancer | Cancer & Oncology | Children | Medulloblastoma | Neurology