Comparison of the effects of soluble corn fiber and fructooligosaccharides on metabolism, inflammation and gut microbiome of high-fat diet fed mice.

Comparison of the effects of soluble corn fiber and fructooligosaccharides on metabolism, inflammation and gut microbiome of high-fat diet fed mice. Am J Physiol Endocrinol Metab. 2020 Aug 24;: Authors: Van Hul M, Karnik K, Canene-Adams K, De Souza M, Van den Abbeele P, Marzorati M, Delzenne NM, Everard A, Cani PD Abstract Dietary fibers are essential components of a balanced diet and have beneficial effects on metabolic functions. To gain insight into their impact on host physiology and gut microbiota, we performed a direct comparison of two specific prebiotics fibers in mice. During an 8-week follow up, mice fed a high-fat diet (HFD) were compared to mice on a normal diet (basal condition, controls) and to mice fed the HFD but treated with one of the following prebiotics: Fructooligosaccharides (FOS) or soluble corn fiber (SCF). Both prebiotic fibers led to a similar reduction of body weight and fat mass, lower inflammation and improved metabolic parameters. However, these health benefits were the result of different actions of the fibers, as SCF impacted on energy excretion, whereas FOS did not. Interestingly, both fibers had very distinct gut microbial signatures with different short chain fatty acid profiles, indicating that they do not favor the growth of the same bacterial communities. Although the prebiotic potential of different fibers may seem physiologically equivalent, our data show that the underlying mechanisms of actio...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research