Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin.

CONCLUSION: The molecular basis of selective inhibition of ALDH-2 by isoflavonoids and related compounds could be related to a more fa-vorable equilibrium relationship between enthalpic and entropic features. The results described herein expand the available knowledge re-garding the physiopathological and therapeutic mechanisms associated with drug addiction.
PMID: 32811404 [PubMed - as supplied by publisher]

Source: CNS and Neurological Disorders Drug Targets - August 16, 2020 Category: Drugs & Pharmacology Authors: da Silva Cunha TT, de Souza FR, Murteira Pinheiro PS, de Sant'Anna CMR, Noël F, Costa França TC, Manssour Fraga CA Tags: CNS Neurol Disord Drug Targets Source Type: research