Differential diagnosis of orthostatic hypotension.

Differential diagnosis of orthostatic hypotension.
Auton Neurosci. 2020 Aug 01;228:102713
Authors: Lei LY, Chew DS, Raj SR
Abstract
Orthostatic hypotension (OH) is a common clinical manifestation characterized by a significant fall in blood pressure with postural change and is frequently accompanied by debilitating symptoms of orthostatic intolerance. The reported prevalence of OH ranges between 5 and 10% in middle-aged adults with a burden that increases concomitantly with age; in those over 60 years of age, the prevalence is estimated to be over 20%. Unfortunately, the clinical course of OH is not necessarily benign. OH patients are at an increased risk of adverse clinical outcomes including death, falls, cardiovascular and cerebrovascular events, syncope, and impaired quality of life. The differential diagnosis of OH is broad and includes acute precipitants as well as chronic underlying medical conditions, especially of neurological origin. Appropriate diagnosis relies on a systematic history and physical examination with particular attention to orthostatic vital signs, keeping in mind that ambient conditions during diagnostic testing may affect OH detection due to factors such as diurnal variation.
PMID: 32805514 [PubMed - as supplied by publisher]

Source: Autonomic Neuroscience - July 31, 2020 Category: Neuroscience Authors: Lei LY, Chew DS, Raj SR Tags: Auton Neurosci Source Type: research