Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart

Conclusion
The signalling pathway governing the inflammasome formation in the heart requires a priming signal in order for an active NLRP3 to induce caspase-1 activation and LV dysfunction.

Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Authors: Toldo, S., Mezzaroma, E., McGeough, M. D., Pena, C. A., Marchetti, C., Sonnino, C., Van Tassell, B. W., Salloum, F. N., Voelkel, N. F., Hoffman, H. M., Abbate, A. Tags: Cardiac biology and remodelling Source Type: research