Regulation of β-catenin by IGFBP2 and its cytoplasmic actions in glioma

ConclusionsIGFBP2 induces TRIM33 which regulates the nuclear β-catenin protein. In addition, IGFBP2 stabilizes the cytoplasmic β-catenin which is involved in the regulation of Oct4 transcript and consequently induction of stemness of glioma cells.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research