Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis: A Randomized Trial.

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis: A Randomized Trial. Am J Respir Crit Care Med. 2020 Aug 06;: Authors: Kyriazopoulou E, Liaskou-Antoniou L, Adamis G, Panagaki A, Melachroinopoulos N, Drakou E, Marousis K, Chrysos G, Spyrou A, Alexiou N, Symbardi S, Alexiou Z, Lagou S, Kolonia V, Gkavogianni T, Kyprianou M, Anagnostopoulos I, Poulakou G, Lada M, Makkina A, Roulia E, Koupetori M, Apostolopoulos V, Petrou D, Nitsotolis T, Antoniadou A, Giamarellos-Bourboulis EJ Abstract Rationale Although early antimicrobial discontinuation guided by procalcitonin (PCT) has showed decreased antibiotic consumption in lower respiratory tract infections (LRTIs), the outcomes in long-term sepsis sequelae remain unclear. Objective To investigate if PCT-guidance may reduce the incidence of long-term infection-associated adverse events in sepsis. Methods In this multicenter trial, 266 sepsis (by Sepsis-3 definitions) patients with LRTIs, acute pyelonephritis, or primary bloodstream infection were randomized (1:1) to receive either PCT-guided discontinuation of antimicrobials or standard-of-care (SOC). The discontinuation criterion was ≥80% reduction in PCT levels or any PCT ≤0.5 μg/l at day 5 or later. The primary outcome was the rate of infection-associated adverse events at day 180, a composite of the incidence of any new infection by Clostridioides difficile or multidrug-resistant organisms (MDRO), or any death attributed...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research

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Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
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Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
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Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Multiple sclerosis Article Source Type: research
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Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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Source: Abdominal Imaging - Category: Radiology Source Type: research
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