Lung carcinoids with high proliferative activity: Further support for the identification of a new tumor category in the classification of lung neuroendocrine neoplasms

The prognosis and therapeutic strategy of lung neuroendocrine neoplasms (NENs) depend on the clinical features of the patients and the accurate characterization of the tumor [1,2]. The World Health Organization (WHO) 2015 classification of lung NENs identifies four distinct categories: typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). This classification relies on three histological criteria: (a) the morphological differentiation status, based on architectural and cytological features, (b) the mitotic count (MC), evaluated by counting the number of mitoses over a 2 mm ² surface, and (c) the presence or absence of tumor necrosis [3].

Source: Lung Cancer - August 6, 2020 Category: Cancer & Oncology Authors: M. Rubino, J.Y. Scoazec, E. Pisa, M. Faron, L. Spaggiari, J. Hadoux, F. Spada, D. Planchard, C.A. Cella, S. Leboulleux, F. De Marinis, M. Ducreux, L. Lamartina, E. Baudin, N. Fazio Source Type: research