Natural alkaloid 8-oxo-epiberberine inhibited TGF- β1-triggred epithelial-mesenchymal transition by interfering Smad3.

In conclusion, OPB inhibited TGF-β1-induced EMT possibly by interfering with Smad3. OPB might have therapeutic potentials for the treatment of metastatic cancers.
PMID: 32745479 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - July 30, 2020 Category: Toxicology Authors: Liu X, Zhang Y, Zhou GJ, Hou Y, Kong Q, Lu JJ, Zhang Q, Chen X Tags: Toxicol Appl Pharmacol Source Type: research