BCCIP β facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma.

In conclusion, this study found a novel interaction between HPV E6 and BCCIPβ in HPV16-positive HNSCC cells. The presence of HPV E6 turned BCCIPβ from a p53 stabilizer to a ubiquitination facilitator. This mechanism helps explain why BCCIPβ acted as a tumor suppressor in HPV-negative HNSCC but exerted oncogenic function in HPV16-positive HNSCC.
PMID: 32736693 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - August 3, 2020 Category: Biochemistry Authors: Wang F, Wang J, Wang J, Zhang L, Fu H, Li J, Tian T, Zuo J, Lv W, Ma X Tags: Biochem Biophys Res Commun Source Type: research