Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?

Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?
J Fam Pract. 2020 Jul/Aug;69(6):309;310;315
Authors: Shehata S, Baker J, Kelsberg G, Safranek S
Abstract
No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary syndrome (ACS) doesn't increase the composite risk of cardiovascular (CV) events: CV death, myocardial infarction (MI), and cerebrovascular accident (CVA) (strength of recommendation: B, randomized, controlled trial [RCT] and prepon-derance of posthoc analyses of large RCTs).
PMID: 32724912 [PubMed - in process]

Source: The Journal of Family Practice - June 30, 2020 Category: Practice Management Authors: Shehata S, Baker J, Kelsberg G, Safranek S Tags: J Fam Pract Source Type: research