Metabolic Profiling of Synthetic Cannabinoid 5F-ADB and Identification of Metabolites in Authentic Human Blood Samples via Human Liver Microsome Incubation and Ultra-High Performance Liquid Chromatography/High-Resolution Mass Spectrometry.

CONCLUSIONS: 5F-ADB is rapidly metabolized in HLM. 5F-ADB, M1 and M5 are pharmacologically active at the cannabinoid receptors (CB1 /CB2 ) and M1 and M5 may contribute to a user's impairment profile. The results demonstrate that it is imperative that synthetic cannabinoid assays screen for pharmacologically active metabolites, especially for drugs with short half-lives. The authors propose that M1 and M5 are appropriate markers to include in laboratory blood tests screening for 5F-ADB. PMID: 32710798 [PubMed - as supplied by publisher]
Source: Rapid Communications in Mass Spectrometry : RCM - Category: Chemistry Authors: Tags: Rapid Commun Mass Spectrom Source Type: research