A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment.

In conclusion, our study suggests that complement C3/C3a receptor signaling plays a key role in LPS-induced cognitive impairments, which may serve a therapeutic target for systemic inflammation related cognitive disorders. PMID: 32707491 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32707491?dopt=Abstract

Source: International Immunopharmacology - July 20, 2020 Category: Allergy & Immunology Authors: Li SM, Li B, Zhang L, Zhang GF, Sun J, Ji MH, Yang JJ Tags: Int Immunopharmacol Source Type: research