Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice

Clinical trials and animal studies have shown that sodium-glucose co-transporter type 2 (SGLT2) inhibitors improve pancreatic beta cell function. Our study aimed to investigate the effect of dapagliflozin on islet morphology and cell phenotype, and explore the origin and possible reason of the regenerated beta cells.

Source: Metabolism - Clinical and Experimental - July 22, 2020 Category: Biomedical Science Authors: Rui Wei, Xiaona Cui, Jin Feng, Liangbiao Gu, Shan Lang, Tianjiao Wei, Jin Yang, Junling Liu, Yunyi Le, Haining Wang, Kun Yang, Tianpei Hong Source Type: research