Evaluation of possible pharmacokinetic interaction between methotrexate and proton pump inhibitors in rats.

CONCLUSION: Esomeprazole increases the t1/2 of MTX in rats, which may be partially attributed to the inhibition of rOAT3.
PMID: 32671657 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - July 14, 2020 Category: Drugs & Pharmacology Authors: Ueda H, Narumi K, Sato Y, Furugen A, Kobayashi M, Iseki K Tags: Pharmacol Rep Source Type: research