An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter [Cell Biology]

Calcium uptake by the mitochondrial calcium uniporter coordinates cytosolic signaling events with mitochondrial bioenergetics. During the past decade all protein components of the mitochondrial calcium uniporter have been identified, including MCU, the pore-forming subunit. However, the specific lipid requirements, if any, for the function and formation of this channel complex...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Sagnika Ghosh, Writoban Basu Ball, Travis R. Madaris, Subramanya Srikantan, Muniswamy Madesh, Vamsi K. Mootha, Vishal M. Gohil Tags: Biological Sciences Source Type: research