Intratumoral retrograde microdialysis treatment of high-grade glioma with cisplatin

ConclusionThis phase I study demonstrates that retrograde microdialysis can be used to administer cisplatin interstitially into high-grade glioma tissue. A high cytotoxicity was detected in tumor tissue, but not in the surrounding brain. Retrograde microdialysis appears to be a clinically useful method for intratumoral drug administration in high-grade glioma.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research