Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.

Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators. Psychol Med. 2020 Jul 06;:1-22 Authors: Sideli L, Murray RM, Schimmenti A, Corso M, La Barbera D, Trotta A, Fisher HL Abstract The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and psychosis. We conducted a systematic search of the PsychINFO, Embase, Ovid, and Web of Science databases for original articles investigating the role of genetic vulnerabilities, environmental factors, psychological and psychopathological mechanisms in the association between CA and psychosis up to August 2019. We included studies with individuals at different stages of the psychosis continuum, from subclinical psychotic experiences to diagnosed disorders. From the 28 944 records identified, a total of 121 studies were included in this review. Only 26% of the studies identified met the criteria for methodological robustness. Overall, the current evidence suggests that CA may be associated with psychosis largely independently of genetic vulnerabilities. More consistent and robust evidence supports interaction between early and recent adversities, as well as the mediating role of attachment and mood...
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research