Induction chemotherapy followed by neoadjuvant chemoradiotherapy and surgery for patients with locally advanced rectal cancer: a systematic review and meta-analysis

ConclusionsThe addition of ICT before NCRT seemingly shows no survival benefit on patients with LARC, and might increase the toxicity.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research

Related Links:

Cir Esp. 2021 Sep 4:S0009-739X(21)00245-1. doi: 10.1016/j.ciresp.2021.07.004. Online ahead of print.ABSTRACTINTRODUCTION: Distance from anal verge of rectal tumors and their anatomical relationships contribute to determine the multidisciplinary therapeutic strategy based on the combination of radio-chemotherapy and radical surgery. Our aims are to investigate which is the most accurate method for the preoperative measuring of the distance from the anal verge in rectal tumors and if the pelvic MRI can substitute the classical instrumental methods.METHODS: Prospective study of diagnostic precision between flexible colonoscop...
Source: Cirugia eEspanola - Category: Surgery Authors: Source Type: research
Mol Clin Oncol. 2021 Oct;15(4):201. doi: 10.3892/mco.2021.2363. Epub 2021 Aug 8.ABSTRACTCirculating tumor cells are an important link between primary tumors and metastases. A longitudinal monitoring of their numbers and properties can provide valuable information on therapy response and disease progression for patients with colorectal cancer. As several techniques for the detection of circulating tumor cells are notorious for yielding low detection rates in patients with non-metastatic colorectal cancer, the present study aimed to perform a proof-of-principle study using the Maintrac® approach for an assessment of circ...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
Clin Colorectal Cancer. 2021 Jul 8:S1533-0028(21)00065-7. doi: 10.1016/j.clcc.2021.06.005. Online ahead of print.ABSTRACTThe standard treatment of locally advanced rectal cancer comprises neoadjuvant chemoradiation followed by total mesorectal excision. This strategy provides low local recurrence rate, however distant recurrence is still an issue and may impact on survival rates. Novel approaches in the neoadjuvant setting have been tested to improve early and late outcomes, as well as to reduce treatment-related toxicity and morbidity. In this review, we discuss the current literature of neoadjuvant treatment in locally a...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
Clin Colorectal Cancer. 2021 Jun 26:S1533-0028(21)00064-5. doi: 10.1016/j.clcc.2021.06.004. Online ahead of print.ABSTRACTPURPOSE: To evaluate the predictive implications and prognosis of mucinous adenocarcinoma (MAC) in locally advanced rectal cancer (LARC) with intensified neoadjuvant treatment.METHODS: Individual patient data of LARC patients from 3 prospective clinical trials was analyzed. Neoadjuvant treatment regimens comprised chemoradiotherapy (CRT) with fluorouracil (5-FU) or mFOLFOX6, neoadjuvant chemotherapy alone with mFOLFOX6 or mFOLFOXIRI. The postoperative pathological result, local recurrence and disease-fr...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
Jpn J Clin Oncol. 2021 Jun 21:hyab095. doi: 10.1093/jjco/hyab095. Online ahead of print.ABSTRACTBACKGROUND: The efficacy of the addition of neoadjuvant chemotherapy to neoadjuvant chemoradiotherapy and total mesorectal excision for locally advanced rectal cancer in elderly patients has not been established.METHODS: A total of 3096 locally advanced rectal cancer patients who received neoadjuvant chemotherapy, along with neoadjuvant chemoradiotherapy and total mesorectal excision, with or without adjuvant chemotherapy, between January 2010 and December 2018, were studied retrospectively. Patients were divided into elderly (&...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsConsidering the study limitations and the lack of randomized studies, further high-quality RCTs are required to confirm the findings of our study.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
AbstractBackgroundIn addition to the direct power of anticancer drugs, the effectiveness of anticancer therapy depends on the host immune function. The present study investigated whether or not the reduction rate and histological response of preoperative chemotherapy were related to the immune microenvironment surrounding a primary tumor of the rectum.MethodsSixty-five patients received preoperative chemotherapy followed by resection from 2012 to 2014; all of these patients were retrospectively analyzed. CD3, CD8, and FoxP3 were immunohistochemically examined as markers for T lymphocytes, cytotoxic T lymphocytes, and regul...
Source: Surgery Today - Category: Surgery Source Type: research
1380Objectives: To evaluate the diagnostic accuracy of [18F]FDG PET/MRI according to our suggested protocol for preoperative staging and usefulness of the detection of extramural vascular invasion (EMVI) for predicting metastasis in rectal cancer. Methods: Twenty-three patients underwent pretreatment [18F]FDG PET/MRI including early delayed and extended PET acquisition and dedicated pelvic MRI without use of anticonvulsant or contrast agents. Seven of them received neoadjuvant chemotherapy (NAC) and all of them subsequently had surgery. Clinical cancer stages were evaluated using postoperative histopathology as a reference...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology - GI & amp;acirc; amp;euro; ' Colorectal and Liver Source Type: research
ConclusionsUnder the care of an experienced multidisciplinary lower gastrointestinal team, NOM is feasible, is safe, and has the potential for improved QoL. A potential algorithm for clinically implementing NOM is described within this review.
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research
Clin Colorectal Cancer. 2021 Feb 27:S1533-0028(21)00020-7. doi: 10.1016/j.clcc.2021.02.006. Online ahead of print.ABSTRACTBACKGROUND: The benefit of adjuvant chemotherapy (AC) is unclear in stage II (cT3-T4 N0) rectal adenocarcinoma (RAC) after neoadjuvant chemoradiation (NCRT) and total mesorectal excision (TME). We aim to identify pathologic factors that influence overall survival (OS) and stratify patients into risk profiles to assess the AC benefit within each profile.PATIENTS AND METHODS: The National Cancer Database for rectal cancer was utilized to identify patients with stage II RAC who completed NCRT and TME. Cox ...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
More News: Biology | Cancer | Cancer & Oncology | Chemotherapy | China Health | Colorectal Cancer | Databases & Libraries | Gastroenterology | Neoadjuvant Chemotherapy Therapy | Neoadjuvant Therapy | Rectal Cancers | Toxicology