Effects of Complement Regulators and Chemokine Receptors in Type 2 Diabetes.

Effects of Complement Regulators and Chemokine Receptors in Type 2 Diabetes. Immunol Invest. 2020 Jul 02;: Authors: Aydin Ozgur B, Coskunpinar E, Bilgic Gazioglu S, Yilmaz A, Musteri Oltulu Y, Cakmakoglu B, Deniz G, Gurol AO, Yilmaz MT Abstract CD55 and CD59 are complement regulatory proteins suggested to be related with progression of diabetes and its complications. The stromal cell-derived factor 1 (SDF-1) and C-X-C chemokine receptor type 4 (CXCR-4) are chemokine proteins. We aimed to investigate the relation of CD55 and CD59 expression levels and polymorphisms of SDF-1 and CXCR-4 with type 2 diabetes mellitus (T2DM) and its complications. Seventy-five T2DM patients and 73 controls were enrolled. Expression levels of CD55 and CD59 were measured by FACS Calibur; qRT-PCR was used to determine SDF-1 and CXCR-4 gene polymorphisms. CD55 and CD59 expressions in patients with nephropathy, retinopathy and cardiovascular disease were significantly lower than controls. Frequency of CXCR-4 T allele carrying was high in patients and created 1.6 fold risk for the disease (p = .07). CXCR-4 a allele carriers had decreased nephropathy; although there was no statistical significance in carrying CXCR-4 T allele, presence of nephropathy was approximately 2 times higher (p = .254). The nephropathy risk increased 10-fold in CXCR-4 TT genotype carriers (p = .02). All SDF-1 CC genotype carriers had retinopathy, so, it was considered that the CC ge...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research