Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells

Conclusions: Aurora-A regulates cell senescence and glucose metabolism to induce cisplatin resistance by participating in the SOX8/FOXK1 signaling axis in ovarian cancer. Our collective findings highlight a novel mechanism of cisplatin resistance and present potential therapeutic targets to overcome chemoresistance in ovarian cancer.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Huizhen Sun, Husheng Wang, Xue Wang, Yoichi Aoki, Xinjing Wang, Yufei Yang, Xi Cheng, Ziliang Wang, Xipeng Wang Tags: Research Paper Source Type: research