Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy

Parkinson's disease affects the peripheral autonomic system and may cause autonomic dysfunction without typical parkinsonian symptoms. This case also underlines the importance of histological sampling of the PNS in cases with autonomic dysfunction. AbstractA 46 ‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research