Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia.

In conclusion, OCA administration during gestation had no apparent detrimental impact on maternal or fetal morphometry and improved fetal hypercholanemia. As high serum bile acid concentrations in ICP are associated with increased rates of adverse fetal outcomes, further investigations into the potential use of OCA during cholestatic gestation are warranted.
PMID: 32597707 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - June 28, 2020 Category: Physiology Authors: Pataia V, McIlvride S, Papacleovoulou G, Ovadia C, McDonald JAK, Wahlström A, Jansen E, Adorini L, Shapiro D, Marchesi JR, Marschall HU, Williamson C Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research