Synthesis, evaluation of antimicrobial activity and molecular docking of new N-1,3-thiazol-2-ylacetamides of condensed pyrido[3',2':4,5]furo(thieno)[3,2-d]pyrimidines.

CONCLUSION: Gram-negative and Gram-positive bacteria and fungi showed different response towards tested compounds, indicating that different substituents may lead to different modes of action or that the metabolism of some bacteria/fungi was better able to overcome the effect of the compounds or adapt to it.
PMID: 32598259 [PubMed - as supplied by publisher]

Source: Current Topics in Medicinal Chemistry - June 27, 2020 Category: Chemistry Authors: Sirakanyan S N, Kartsev V G, Geronikaki A, Spinelli D, Petrou A, Hakobyan E K, Glamoclija Ja, Ivanov M, Sokovic M, Hovakimyan A A Tags: Curr Top Med Chem Source Type: research