Relapsing-remitting multiple sclerosis: A profile of interleukine-1 gene cluster polymorphisms in Iraqi patients

In this case-control study, 68 relapsing-remitting multiple sclerosis (RRMS) patients and 133 control were genotyped for IL1A −889 (rs1800587), IL1B−511 (rs16944), IL1B+3962 (rs1143634), IL1R1pst11970 (rs2234650) and IL1RNmspa1 11,100 (rs315952) variants. Sequence-specific-primer-polymerase-chain-reaction was the genotyping method. Logistic regression analysis demonstrated protective effects of IL1B−511, IL1R1pst1197 0 and IL1RNmspa1 11,100 against MS incidence, while no association was found with IL1A−889 and IL1B+3962 variants.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research