Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF- κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models

ConclusionThese results suggest new insights into the protective role of Peli1 on ischemic tissues and its influence on survival signaling.
Source: Basic Research in Cardiology - Category: Cardiology Source Type: research