Intravenous injection of Muse cells as a potential therapeutic approach for epidermolysis bullosa

Multilineage-differentiating stress-enduring (Muse) cells, positive for stage-specific embryonic antigen (SSEA)-3, are endogenous pluripotent-like stem cells that reside in the bone marrow, peripheral blood and connective tissue of organs, and correspond to several percent of cultured mesenchymal stem/stromal cells (MSCs) and fibroblasts (Kuroda et al., 2010). As shown by animal models of acute myocardial infarction, stroke and chronic kidney disease, intravenously injected Muse cells specifically home to damaged sites via the sphingosine-1-phosphate (S1P, produced by damaged cells) – S1P receptor 2 (expressed on Muse cells) axis and replace damaged/apoptotic cells by spontaneously differentiating into tissue-constituent cells to repair the organ (Uchida et al., 2016, Uchida H.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research