How Often Does Modern Neoadjuvant Chemotherapy Downstage Patients to Breast-Conserving Surgery?

ConclusionIn patients with large tumors precluding BCS, conversion to BCS eligibility was high with NAC, particularly in bBCS candidates. HER2+/TN receptor status predicted successful downstaging, while lower downstaging rates were observed with larger tumors, cN+ status, and calcifications. These factors should be considered when selecting patients for NAC.

http://link.springer.com/10.1245/s10434-020-08593-5

Source: Annals of Surgical Oncology - June 7, 2020 Category: Cancer & Oncology Source Type: research