Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer

ConclusionsThe findings suggest that ccRCC and pRCC differ with respect to PD-L1 regulation by IFN- γ-signaling. HighPD-L1-mRNA levels in tumor tissues with a positive IFN- γ signature favorably affect OS and DFS.

Source: Targeted Oncology - June 2, 2020 Category: Cancer & Oncology Source Type: research