Severity and duration of hypoxic stress differentially regulates HIF-1 α-mediated cardiomyocyte apoptotic signaling milieu during myocardial infarction.

CONCLUSION: ROS-mediated HIF-1α stabilization promotes cardiomyocyte apoptosis on one hand while NO-mediated stabilization of HIF-1α disrupts apoptosis depending upon the severity and duration of hypoxia. Therefore the outcome of modulation of cardiac HIF-1α activity is regulated by both the severity and duration of ischemic stress. PMID: 32473132 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32473132?dopt=Abstract

Source: Archives of Biochemistry and Biophysics - May 26, 2020 Category: Biochemistry Authors: Chaudhuri RD, Banerjee D, Banik A, Sarkar S Tags: Arch Biochem Biophys Source Type: research