Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche

Intracerebroventricular (i.c.v.) infusion of norepinephrine (NE) decreases neuroprogenitor cell (NPC) proliferation (arrows) within the subventricular zone (SVZ) of the lateral ventricles (LV) and neurogenesis in the SVZ ‐olfactory bulb system without changing cells type composition of the SVZ. In contrast, pharmacological NE inhibition increases the proliferation of various NPC types and early neurogenesis events in the caudal periventricular niche (PGN) of the third ventricle (3 V). Neurotoxic ablation of nore pinephrine neurons within theLocus coeruleus (LC) using Dsp4 confirms the inhibitory effects of NE on NPC proliferation within the 3  V‐PGN. This effect is reversed by NE i.c.v. infusion. Contrarily, NE depletion largely impairs NPC proliferation within the hippocampus in the same animals. Our data indicate that NE has opposite effects on the two fundamental neurogenic niches of the adult brain with norepinephrine being a neg ative regulator of adult periventricular neurogenesis. AbstractThe limited proliferative capacity of neuroprogenitor cells (NPCs) within the periventricular germinal niches (PGNs) located caudal of the subventricular zone (SVZ) of the lateral ventricles together with their high proliferation capacity after isolation strongly implicates cell ‐extrinsic humoral factors restricting NPC proliferation in the hypothalamic and midbrain PGNs. We comparatively examined the effects of norepinephrine (NE) as an endogenous candidate regulator of PG...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research