Cancers, Vol. 12, Pages 1417: Fanconi Anemia Pathway Activation by FOXM1 Is Critical to Bladder Cancer Recurrence and Anticancer Drug Resistance
In conclusion, FOXM1 and FANCD2 can be used as prognostic factors that are associated with high risk of recurrence and with anticancer drug resistance properties in NMIBC patients.
Publication date: Available online 12 July 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): A. Biggerstaff, B. Kivell, J.L. Smith, Md Y. Mian, L.K. Golani, F. Rashid, D. Sharmin, D.E. Knutson, R. Cerne, J.M. Cook, J.M. Witkin
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05989J, PaperK S Sharma, A. K. Dubey, Arunkumar S, Koijam, Chandan Kumar, Anand Ballal, Sudip Mukherjee, Prasad P Phadnis, R K Vatsa Abstract Water soluble Pt(IV) prodrug of cisplatin was synthesized by oxidation of cisplatin followed by treatment with succinic anhydride to achieve easily reducible ester linkage at axial positions which was... The content of this RSS Feed (c) The Royal Society of Chemistry
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02844D, PaperMuhammad Khattab, Ahmed A. Al-Karmalawy Preclinical and clinical studies on Mebendazole revealed its potential as anticancer agent. We therefore aimed to investigate its binding interactions with one of the most important cancer targets (Tubulin protein)... The content of this RSS Feed (c) The Royal Society of Chemistry
Mice that experienced heart attacks underwent a large-scale shift in their immune systems that allowed cancer to flourish, perhaps explaining the observation in patients.
Conclusion: In this cohort of patients with esophageal cancer admitted to intensive care units with acute illness, the in-hospital mortality rate was very high. The requirement for invasive mechanical ventilation and metastatic disease were independent prognostic factors and should be considered in discussions about the short-term outcomes of these patients.
Loss of chromosome Y (LOY) is a mosaic aneuploidy that can be detected mainly in blood samples of male individuals. Usually, LOY occurrence increases with chronological age in healthy men. Moreover, recently LOY has been reported in association with several diseases, such as cancer, where its frequency is even higher. The Y chromosome is one of the shortest chromosomes of the human karyotype, and it is crucial for correct male development. This chromosome has functions beyond the male reproductive system, and loss of its genes or even LOY can have consequences for the male body that are yet to be elucidated. Analyses of th...
ConclusionsAortoiliac calcification may be considered a risk factor for grade C AL after rectal cancer surgery.
This study analyzed the genetic susceptibility of gene polymorphisms in three patients with multiple primary malignant neoplasms and examined the possible pathogenesis. The clinical data and whole genome sequence of three patients (1 with 5 primary cancers, 1 with 4 primary cancers, and 1 with 3 primary cancers) were aligned with a series of databases. We found the three patients contained a total of seven types of malignant tumours (endometrial cancer, ovarian cancer, breast cancer, colon cancer, ureter cancer, bladder cancer and kidney cancer). It was found that the varied genes in Patient 1 (5 primary cancers) were BRIP...
Opa interacting protein 5 (OIP5) has previously been identified as a tumorigenesis gene. The purpose of this study is to explore the role of OIP5 in the progression of bladder cancer (BC). The OIP5 expression and clinical behaviors in bladder cancer were collected from lager database. Our study showed that OIP5 was highly expressed in bladder cancer tissues and cells. Overexpression of OIP5 in tumor patients predicted worse overall survival (OS) and higher histological grade. Vitro and vivo experiments demonstrated that knockdown of OIP5 significantly inhibited cell growth of BC. Scratch assay and transwell assay suggested...
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.6b00076