Tripartite motif 8 (TRIM8) plays a protective role in a cell model of Parkinson's disease via modulation of NF- κB activation through targeting of IκBα ubiquitination.

In conclusion, silencing of TRIM8 plays a protective role in the cell model of PD by inhibiting NF-κB activation through IκBα ubiquitination. PMID: 32463919 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32463919?dopt=Abstract

Source: Clinical and Experimental Pharmacology and Physiology - May 27, 2020 Category: Drugs & Pharmacology Authors: Pang Y, Rong Y, Zhu S, Pei H Tags: Clin Exp Pharmacol Physiol Source Type: research