Cancers, Vol. 12, Pages 1406: The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response

Cancers, Vol. 12, Pages 1406: The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response Cancers doi: 10.3390/cancers12061406 Authors: Sánchez-Alcoholado Ramos-Molina Otero Laborda-Illanes Ordóñez Medina Gómez-Millán Queipo-Ortuño Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota can alter CRC susceptibility and progression by modulating mechanisms such as inflammation and DNA damage, and by producing metabolites involved in tumor progression or suppression. Dysbiosis of gut microbiota has been observed in patients with CRC, with a decrease in commensal bacterial species (butyrate-producing bacteria) and an enrichment of detrimental bacterial populations (pro-inflammatory opportunistic pathogens). CRC is characterized by altered production of bacterial metabolites directly involved in cancer metabolism including short-chain fatty acids and polyamines. Emerging evidence suggests that diet has an important impact on the risk of CRC development. The intake of high-fiber diets and the supplementation of diet with polyunsaturated fatty acids, polyphenols and probiotics, which are known to regulate gut microbiota, could be not only a potential mechanism for the reduction of CRC risk in a primary prevention setting, but may also be important to enhance the response to cancer therapy when used as ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research