Clopidogrel combats neuroinflammation and enhances learning behavior and memory in a rat model of Alzheimer's disease

Publication date: Available online 29 May 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Noura El Adle Khalaf, Farida Mohamed El Banna, Mona Younis Youssef, Youssef Mohammed Mosaad, Mohamed-Hesham Yousry Daba, Rehab Hamdy Ashour
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research

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Authors: Olsen I, Singhrao SK PMID: 32663042 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
This article reviews key drugs that have been discontinued while in development for AD and delineates the future landscape for present and alternative approaches. EXPERT OPINION: Anti-Aβ drugs have failed to validate the Aβ cascade hypothesis of AD. Early findings suggest that the same is happening with therapeutics targeting tau and focussing future research solely on anti-tau drugs is inappropriate. Alternative targets should be pursued, including apolipoprotein E, immunomodulation, plasma exchange, protein autophagy and clearance, mitochondrial dysfunction, abnormal glucose metabolism, neurovascular unit s...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
CONCLUSIONS: We found that ESRD patients exhibited decreased structural and functional brain connectivities, and that there was a significant association between brain connectivity and cognitive function. These alterations in the brain network may contribute to the pathophysiological mechanism of CI in ESRD patients. PMID: 32657059 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Dementia is a syndrome and an umbrella term that encompasses Alzheimer, Parkinson and autism diseases. These diseases are by far the most common cause of dementia; therefore this investigation will chiefly include these disorders, with a limited discussion of few other disorders related to dementia. Alzheimer’s disease (AD) is characterized by the accumulation of cerebral β-amyloid plaques, tau proteins and memory loss; Parkinson by the deterioration of brain cells which regulate the movement of body parts and produce dopamine; and autism by abnormalities of social disorder and difficulty in communicating and fo...
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Cerebral vascular dysfunction is associated with various neurological disorders, which often share some common mechanisms with cardiovascular diseases especially Coronary Artery Disease (CAD).1 –6 Pin1 (encoded by the PIN1 gene) is a key enzyme in humans and is implicated in Alzheimer disease by suppressing amyloid–β deposition and tau aggregation.7–11 Recently, we hypothesized that Pin1 may cause cerebrovascular atherosclerosis and aggravate ischemia-related neurological disorders. 12 However, the relationship between the genetic polymorphisms of PIN1 and vascular atherosclerosis in humans is still not clear.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
This study examined the need for age-friendly efforts to include dementia-friendly educational opportunities by providing information about undergraduate students' personal experience, knowledge, and concern regarding dementia and Alzheimer's disease (D/AD), along with their interest in D/AD educational support. A total of 106 students responded (30% response rate) to an online survey distributed in diverse classes, with more than 50% of students indicating that they had experience with someone with D/AD, primarily a grandparent. Students showed low levels of knowledge and strong concern about developing D/AD, confirming t...
Source: Gerontology and Geriatrics Education - Category: Geriatrics Tags: Gerontol Geriatr Educ Source Type: research
A protein linked to brain damage in people with Alzheimer ’s disease may come from the gut, which could lead to new therapies to prevent the condition
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
An imaging technique that combines F-18 FDG PET and MRI was able to pinpoint...Read more on AuntMinnie.comRelated Reading: SNMMI 2020: How nuclear medicine handled COVID-19 SNMMI 2020: Medical students key to the specialty's future PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse Biomarkers on PET, MRI show breast cancer risk
Source: Headlines - Category: Radiology Source Type: news
In this study, we show that GF and ABX-treated 5x familial AD (5xFAD) mice developed attenuated hipp ocampal Aβ pathology and associated neuronal loss, and thereby delayed disease-related memory deficits. While Ab production remained unaffected in both GF and ABX-treated 5xFAD mice, we noticed in GF 5xFAD mice enhanced microglial Aβ uptake at early stages of the disease compared to ABX-treated 5x FAD mice. Furthermore, RNA-sequencing of hippocampal microglia from SPF, GF and ABX-treated 5xFAD mice revealed distinct microbiota-dependent gene expression profiles associated with phagocytosis and altered microglial a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Wruck Wasco ; Martins Soraia ; Bohndorf Martina ; Adjaye JamesSeries Type : Expression profiling by arrayOrganism : Homo sapiensRecently, genes associated with immune response and inflammation have been identified as genetic risk factors for late-onset Alzheimer's disease (LOAD). One of them is the rare p.Arg47His (R47H) variant within triggering receptor expressed on myeloid cells 2 (TREM2), which has been shown to increase the risk for developing AD 2-3-fold. Here, we report the generation and characterization of a model of LOAD using lymphoblast-derived iPSCs from patients harbouring the R47H mutation in ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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